Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons

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Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a.

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Unraveling mechanisms underlying epileptogenesis after brain injury is an unmet medical challenge. Although histopathological studies have revealed that reactive astrogliosis and tissue acidosis are prominent features in epileptogenic foci, their roles in epileptogenesis remain unclear. Here, we explored whether astrocytic acid-sensing ion channel-1a (ASIC1a) contributes to the development of c...

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Corrigendum: Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Chronic Epileptogenesis

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the mater...

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Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice

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ژورنال

عنوان ژورنال: Journal of Neuroinflammation

سال: 2015

ISSN: 1742-2094

DOI: 10.1186/s12974-015-0465-7